BackgroundHIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART), the most effective treatment for HIV infection currently available.However, HIV PIs have now been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular disease and metabolic syndrome.Our previous studies ha
There are many moving machine assemblies with conformal tribological contacts at very high contact pressures, e.g., sliding bearings, propeller shaft bearings and machine guideways.Furthermore, applications such as trunnion and guide vane bearing in Kaplan turbines have very low sliding speeds and oscillatory types of motion.Although there is a vas
BackgroundUltra close-range digital photogrammetry (UCR-DP) is emerging as a robust technique for 3D model generation and represents a convenient and low-cost solution for rapid data acquisition in virtual anthropology.ObjectivesThis systematic review aims to analyse applications, technical implementation, and performance of UCR-DP in skeletal anth
Pompe disease is a lysosomal storage disorder in which acid alpha-glucosidase is deficient or absent.Deficiency of this lysosomal enzyme results in progressive expansion of glycogen-filled lysosomes in multiple tissues, with cardiac and skeletal muscle being the most severely affected.The clinical spectrum ranges from fatal hypertrophic cardiomyopa
Increasing evidence shows that dysregulation of microRNAs (miRNAs) is involved in malignant transformation.We investigated the clinical significance of miR-650 and its involvement in chemoresistance to docetaxel.Our results showed that the relative expression level of miR-650 was significantly higher in LAD tissues than in corresponding nontumor ti